Sub Optimal UI?
If all it is is a web page in a frameless Chrome window, then it's still going to look like a web page. That is, it'll look pretty rubbish when a page is trying to pretend to be an application with dialogue boxes, menus, etc. Who has ever heard of a dialogue box for a proper native application that cannot be moved outside of the frame of the application's window?
And another point, boring but important, is that in company environments where there's people who aren't especially IT literate, having a consistent style and way of doing things like accessing menus, and so forth, is actually quite important. Having all that consistency tossed in the bin on a regular basis because some web developer has got the horn for some latest fancy toolbox on NMP is not helpful...