Would be very, very interested in seeing what the standby power consumption is like on those chips as down at that size, current leakage starts to dominate, you can have real trouble actually turning anything off, primarily due to quantum tunnelling and thermal effects.
It can also really affect reliability, process tolerances are insanely tight and, as you're already operating at the limit, a tightly controlled gate can still have false switches due to the aforementioned quantum tunnelling and thermal effects. Once you combine process drift with them, you find the percentage of gates performing unpredictably can rise significantly.
Not showstoppers, but a huge engineering challenge.