The Xperia Z3 / Z3 Compact seem to be the more relevant devices to compare this to than the iPhone.
So, do you want waterproofing, an SDCard slot and a very good battery, or do you want a fingerprint scanner and a removable - but only so-so - battery? Samsung's and Sony's varying degrees of Android skinning and bloatware might also be a consideration for some.
To be honest though, none of current flagship Android phones are bad...even the ones from a year ago, such as the LG G2, can still hold their own in the speed, battery life and camera stakes (and be found for a helluva lot less money)