keep your customers informed....
Every system has downtime, and hosted services tend to be far more resilient than machines in a cupboard at the back of the office. But what's really vital is letting your customers know what's going on, as my host, 1&1, singularly failed to do during a recent email outage. No status panel, nothing anywhere on their website or management portal, nothing on Twitter, no explanation at all, just no SMTP and no webmail for about 3 hours.
All they'd needed to do was to post a status message saying, we are having problems with our email servers, we expect the problem to be fixed in X hours, and I could probably have lived with it a lot more easily than having no idea when my email was going to work again